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KMID : 1123920070210061576
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 6 p.1576 ~ p.1580
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Anti-aging Activity of Aralia Cordata Thunb. by Inhibiting Oxidized Low-dencity Lipoprotein Production in Rats
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Hyun Min-Kyung
Jung Ji-Chun
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Abstract
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Aralia cordata Thunb. (Araliaceae, ACT) is an remarkable herbal plant that has been widely used in traditional oriental medicine for the treatment of inflammatory diseases and cardiovascular disorders. In this study, we have established a vascular aging model in rats by orally administrating excessive vitamin (500,000 IU/kg/day) for 4 days followed by feeding high cholesterol diet for 16 weeks and then rats were randomly divided into control group, high cholesterol diet (HCD) group, HCD+ACT (30 mg/kg) and HCD+ACT (60 mg/kg) group. ACT (30, 60) significantly reduced total cholesterol (TC) content compared with HCD, but no significant differences in the serum lipids. Secondly, we measured the serum levels of Oxidized Low-dencity Lipoprotein (OxLDL) and malondialdehyde (MDA) in order to further investigate the anti-vascular aging mechanism of ACT. The results, ACT (30, 60) treatments decreased OxLDL, MDA content and increased Cu/Zn superoxide dismutase activity compared with HCD treatments. The results suggested that ACT inhibited OxLDL production rather than serum lipids lowering and that ACT could be used as potential anti-atherosclerotic agent in aged cells.
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KEYWORD
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Aralia cordata Thunb, Oxidized Low-dencity Lipoprotein, malondialdehyde, Cu/Zn superoxide dismutase, Cytotoxic, ity
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